Understanding how CBD works in pets helps explain why it shows broad therapeutic potential.

• Metabolism differences: Dogs produce 6-OH-CBD as their main metabolite, unlike humans who produce 7-OH-CBD and 7-COOH-CBD.

• Receptor activity: CBD interacts with CB1/CB2 (neuromodulation, immune balance), TRPV1 (pain, inflammation), PPARγ (anti-inflammatory gene regulation), and GPR55 (seizure modulation).

• CBDA advantage: CBDA may have 3–5x higher oral absorption than CBD, suggesting enhanced bioavailability in some formulations.

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Important to know for pet owners

• CBD is a multi-target supplement, which explains why it may help with different conditions.

• Absorption can vary by species, product, and whether it’s given with food.

• Product quality is essential—choose third-party tested brands.

Important to know for veterinarians

• Species-specific metabolism means dogs and cats cannot be dosed like humans.

• Multi-receptor action creates wide-ranging effects—but also potential for off-target interactions.

• Research into CBDA and cannabinoid synergies may inform future veterinary therapeutics.

Final Thoughts

CBD shows promise in managing osteoarthritis, seizures, anxiety, and dermatological issues in pets. Evidence supports 2–5 mg/kg/day as a safe and potentially effective range, with veterinary monitoring.

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